KPV | Research Grade | COA Verified

Description

Research area: Epithelial and mucosal inflammation signaling models

Product Description

KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, corresponding to residues 11-13 (Lys-Pro-Val) of the parent hormone. As a minimal three-amino-acid fragment, it retains the anti-inflammatory character associated with alpha-MSH while lacking the residues responsible for pigment-driven melanocortin signaling. This makes KPV a widely used tool in laboratory studies of resolution biology, since investigators can probe cytokine and transcription-factor pathways without confounding receptor-mediated pigmentation effects. Its small size and reported stability in intestinal-epithelial and gut-lumen model systems have made it a frequent reference compound for studying peptide-based modulation of mucosal inflammatory responses in vitro and in preclinical animal tissue.

Mechanism & Research Context

In cell and animal models, KPV is studied for its ability to attenuate NF-kappaB signaling, reportedly by interfering with p65/RelA nuclear translocation and limiting IkappaB-alpha degradation, thereby lowering pro-inflammatory cytokine output. Research also examines effects on MAP-kinase cascades and on macrophage activation markers such as CD86 in intestinal-epithelial and immune-cell cultures. Some models explore uptake through the peptide transporter PepT1, framing KPV as a probe of NF-kappaB-dependent inflammatory pathways.

Research Applications

• In-vitro screening of NF-kappaB pathway modulation in intestinal epithelial cells
• Preclinical models of colitis and mucosal barrier inflammation
• Study of pro-inflammatory cytokine suppression in macrophage cultures
• Investigation of PepT1-mediated peptide uptake in gut tissue
• Comparative research versus full-length alpha-MSH without pigmentation confounds

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Melanocortin-derived tripeptide (Lys-Pro-Val)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of KPV is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

KPV is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.