PT-141 | Research Grade | COA Verified

Description

Research area: Central melanocortin receptor signaling research

Product Description

PT-141, or bremelanotide, is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) derived from the melanocortin agonist melanotan II. It preserves the conserved His-Phe-Arg-Trp pharmacophore of alpha-melanocyte-stimulating hormone, while a lactam bridge locks the backbone into a constrained ring. This truncation and cyclization shift its receptor preference toward the central MC3R and MC4R subtypes and away from the MC1R pigmentation receptor emphasized by its parent molecule. With a molecular weight near 1025 Da and improved metabolic stability, it serves as a well-characterized probe for interrogating melanocortin signaling in laboratory neuroscience and receptor-pharmacology models.

Mechanism & Research Context

In receptor and cell-based assays, PT-141 binds central melanocortin receptors, chiefly MC4R and MC3R, coupling to Gs proteins that activate adenylyl cyclase and raise intracellular cyclic AMP with downstream protein kinase A signaling. Preclinical work uses it to map melanocortin circuitry in the hypothalamic paraventricular nucleus and preoptic regions, characterize CNS-mediated signaling distinct from peripheral vascular pathways, and profile receptor selectivity, binding kinetics, and cAMP concentration-response in transfected and neuronal research systems.

Research Applications

• MC3R/MC4R binding affinity and selectivity assays
• cAMP and protein kinase A signaling readouts in transfected cells
• Mapping hypothalamic melanocortin circuitry in rodent models
• Comparative pharmacology against melanotan II and alpha-MSH
• Peptide stability and structure-activity studies of the lactam-bridged core

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic cyclic heptapeptide melanocortin agonist
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of PT-141 is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

PT-141 is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.