N-Acetyl Selank Amidate | Research Grade | COA Verified

Description

Research area: Anxiolytic and neuromodulatory peptide research

Product Description

N-Acetyl Selank Amidate is a chemically stabilized form of Selank, a synthetic heptapeptide derived from the endogenous immunomodulatory tetrapeptide tuftsin, extended with additional residues for enhanced activity. In this variant an acetyl group caps the N-terminus and an amide group caps the C-terminus, protecting the peptide from exopeptidase degradation and extending its functional half-life in experimental systems. Developed within Russian neuropeptide research, it is investigated as a tool compound for studying peptide-based modulation of central nervous system signaling. Its terminal modifications distinguish it from unmodified Selank, making it a frequently referenced construct in stability-focused and neuropharmacological research on short regulatory peptides.

Mechanism & Research Context

In animal and cell models N-Acetyl Selank Amidate is reported to cross the blood-brain barrier and modulate multiple CNS systems. Research examines its influence on GABA-A-linked inhibitory signaling, serotonergic neurotransmission and 5-HT metabolism, and opioidergic pathways. It is also studied for increasing expression of brain-derived neurotrophic factor (BDNF) and its TrkB receptor in hippocampal and cortical tissue, providing a neurotrophic mechanism examined alongside its effects on anxiety-related and cognition-related behavioral models.

Research Applications

• Rodent behavioral models of anxiety and stress response
• Study of BDNF/TrkB expression in hippocampal and cortical tissue
• Investigation of GABAergic inhibitory signaling modulation
• Research on serotonergic neurotransmission and 5-HT metabolism
• Peptide-stability comparison versus unmodified Selank in vitro

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic tuftsin-analogue heptapeptide (acetylated, amidated)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of N-Acetyl Selank Amidate is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

N-Acetyl Selank Amidate is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.