Semaglutide | Research Grade | COA Verified

Description

Research area: GLP-1 receptor incretin signaling research

Product Description

Semaglutide is a synthetic 31-amino-acid analogue of human GLP-1(7-36) engineered for metabolic stability. It carries an Aib8 substitution that resists dipeptidyl peptidase-4 cleavage, an Arg34 substitution, and a C18 diacid fatty-acid chain attached at Lys26 through a gamma-Glu and two OEG spacers, promoting albumin binding and a prolonged circulating half-life. With a molecular weight near 4114 Da, it is a single-receptor GLP-1 agonist, distinguishing it from dual and triple agonists. These modifications make semaglutide a standard reference ligand for probing GLP-1 receptor pharmacology and long-acting peptide design in laboratory and animal metabolic-research models.

Mechanism & Research Context

Semaglutide binds the GLP-1 receptor, a class B G-protein-coupled receptor, activating Gs-coupled adenylyl cyclase to elevate cyclic AMP and drive downstream signaling. In research models it is studied for glucose-dependent insulinotropic signaling in pancreatic beta-cell systems, glucagon-secretion modulation, gastric-emptying and appetite-related neural pathways, and receptor internalization and beta-arrestin dynamics. Cell-based cAMP assays, receptor-binding studies, and rodent metabolic experiments characterize its potency and durable GLP-1 receptor engagement.

Research Applications

• GLP-1 receptor binding and cAMP potency assays
• Glucose-dependent insulin secretion studies in beta-cell lines
• Albumin-binding and half-life characterization of acylated analogues
• Appetite and gastric-emptying pathway research in rodent models
• DPP-4 resistance and peptide-stability comparisons

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Acylated GLP-1 receptor agonist analogue peptide
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Semaglutide is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Semaglutide is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.