Sermorelin | Research Grade | COA Verified

Description

Research area: GHRH receptor and somatotroph signaling research

Product Description

Sermorelin is a synthetic 29-amino-acid peptide reproducing the biologically active N-terminal fragment of human growth-hormone-releasing hormone, GHRH(1-29)NH2, with a C-terminal amide and a molecular weight near 3358 Da. Although native GHRH spans 44 residues, its full receptor-binding and functional activity resides in these first 29 amino acids, making sermorelin a compact, potent GHRH surrogate. As a releasing-hormone analogue it acts upstream at the pituitary rather than supplying growth hormone directly, preserving physiological feedback in experimental systems. This makes it a standard research ligand for interrogating GHRH receptor pharmacology and somatotroph secretory dynamics in cell and animal models.

Mechanism & Research Context

Sermorelin binds the GHRH receptor, a class B G-protein-coupled receptor on anterior-pituitary somatotrophs, activating Gs-coupled adenylyl cyclase to raise cyclic AMP and stimulate growth-hormone synthesis and pulsatile release. In research models the pituitary feedback loop stays intact, with somatostatin providing negative regulation. It is used to study GHRH receptor binding and desensitization, somatotroph cyclic-AMP responses, and pulsatile secretory patterns in cultured pituitary cells and rodent endocrine experiments.

Research Applications

• GHRH receptor binding and cAMP response assays
• Somatotroph growth-hormone secretion studies in pituitary cell culture
• Pulsatile secretion and somatostatin feedback modeling in rodents
• Structure-activity comparison against full-length GHRH(1-44)
• Receptor desensitization and signaling-kinetics investigations

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic GHRH(1-29) analogue peptide
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Sermorelin is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Sermorelin is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.