Snap-8 | Research Grade | COA Verified

Description

Research area: SNARE complex assembly and exocytosis research

Product Description

SNAP-8, known by its INCI name acetyl octapeptide-3, is a synthetic acetylated octapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp and a molecular weight near 1076 Da. It is modeled on the N-terminal region of SNAP-25, the synaptosomal-associated protein that contributes two of the four helices forming the neuronal SNARE complex. An extended analogue of the hexapeptide argireline, SNAP-8 is distinguished by its longer sequence and by acting as a mimetic that competes for SNARE assembly sites. This makes it a useful tool compound for studying SNARE-dependent vesicle fusion and neurotransmitter-release mechanisms in cell-culture and biochemical research.

Mechanism & Research Context

SNAP-8 presents a sequence mirroring the SNAP-25 N-terminus and is studied as a competitive interferer with SNARE four-helix-bundle assembly, disrupting alignment of syntaxin, synaptobrevin, and SNAP-25 helices. Unlike botulinum toxin’s irreversible proteolytic cleavage, this competitive, reversible mechanism reduces rather than abolishes vesicle-fusion efficiency. In vitro, it has been reported to lower stimulated neurotransmitter release, and it is used to probe exocytosis and SNARE-modulation pathways in neuronal and secretory-cell research models.

Research Applications

• Competitive SNARE-assembly inhibition assays with SNAP-25 constructs
• Stimulated neurotransmitter-release quantification in cell culture
• Comparative studies versus argireline and Leuphasyl peptides
• Vesicle-fusion and exocytosis mechanism research in neuronal models
• Reversible SNARE-modulation kinetics versus proteolytic cleavage controls

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic acetylated octapeptide (acetyl octapeptide-3)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Snap-8 is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Snap-8 is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.