Survodutide | Research Grade | COA Verified

Description

Research area: Dual GLP-1 and glucagon receptor signaling research

Product Description

Survodutide (BI 456906) is a synthetic, acylated 29-amino-acid dual-agonist peptide derived from the glucagon backbone and engineered to activate both the glucagon and GLP-1 receptors. Selected residues are exchanged for GLP-1 and exendin-4 amino acids, position 2 carries the unnatural residue Ac4c for enzymatic stability, and a C18 fatty-diacid side chain linked through a glycine-serine spacer enables albumin binding and extended circulation. With balanced, sub-nanomolar potency at both receptors, it occupies a middle ground between single GLP-1 agonists and triple agonists, serving as a reference tool for studying combined incretin and glucagon-axis pharmacology in metabolic-research models.

Mechanism & Research Context

Survodutide co-activates the glucagon and GLP-1 receptors, both class B G-protein-coupled receptors signaling through Gs-adenylyl-cyclase and cyclic AMP. In preclinical and cell-based research the GLP-1 arm is studied for insulinotropic and appetite-related signaling and delayed gastric transit, while the glucagon arm is examined for increased energy expenditure and hepatic fatty-acid oxidation. Comparative cyclic-AMP and receptor-potency assays characterize its balanced dual-receptor engagement and separable metabolic-pathway contributions.

Research Applications

• Dual GLP-1 and glucagon receptor potency and cAMP assays
• Energy-expenditure and thermogenesis studies in rodent models
• Hepatic fatty-acid oxidation and steatosis research in animal models
• Balanced dual-agonism profiling versus single and triple agonists
• Albumin-binding and circulating-stability characterization of the acylated scaffold

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic acylated dual-agonist peptide (GLP-1/glucagon)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Survodutide is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Survodutide is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.