Tesamorelin/Ipamorelin Blend | Research Grade | COA Verified

Description

Research area: Dual-pathway growth-hormone secretagogue interaction research

Product Description

This blend combines two distinct growth-hormone-axis research peptides that act through separate receptor systems. Tesamorelin is a stabilized 44-amino-acid analogue of GHRH, N-terminally modified with trans-3-hexenoic acid to resist proteolysis and engage the pituitary GHRH receptor. Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2, ~712 Da) that selectively agonizes the ghrelin receptor GHS-R1a and is noted for releasing growth hormone without markedly elevating cortisol or prolactin. Paired together, the two represent complementary upstream routes to GH secretion, and the blend is studied to examine how simultaneous GHRH-receptor and ghrelin-receptor stimulation interact in preclinical models.

Mechanism & Research Context

The two components engage parallel but independent receptors. Tesamorelin activates the Gs-coupled GHRH receptor on somatotrophs, raising cAMP via adenylate cyclase/PKA. Ipamorelin activates the Gq-coupled GHS-R1a ghrelin receptor, driving phospholipase-C, IP3, and intracellular calcium release. Because these converge on growth-hormone exocytosis through different second messengers, research uses the combination to probe potential additive or synergistic GH-secretory responses, receptor cross-talk, and selectivity profiles in cultured pituitary cells and animal models.

Research Applications

• Combined GHRH-receptor and GHS-R1a signaling studies
• Additive versus synergistic GH-secretion assays in vitro
• Receptor cross-talk and second-messenger comparison research
• Cortisol- and prolactin-selectivity profiling of the ipamorelin component
• Pulsatile GH-release dynamics in animal models

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Blend of a GHRH analogue and a selective GHS-R1a pentapeptide agonist
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Tesamorelin/Ipamorelin Blend is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Tesamorelin/Ipamorelin Blend is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.