Thymulin / Thymalin | Research Grade | COA Verified

Description

Research area: Zinc-dependent thymic immune-regulation research models

Product Description

This listing references two related but distinct thymic research materials. Thymulin (facteur thymique serique, FTS) is a defined zinc-dependent nonapeptide (Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn) secreted by thymic epithelial cells, whose biological conformation and activity strictly require an equimolar bound zinc ion. Thymalin, by contrast, is not a single peptide but a polypeptide complex extracted from calf thymus, containing multiple thymic factors. Thymulin is thus a purified, sequence-defined metallopeptide, whereas thymalin is a mixed extract. Both are studied in immune-regulation research, and the zinc requirement in particular distinguishes thymulin from other thymic peptides such as thymosin alpha-1.

Mechanism & Research Context

Thymulin’s activity depends on coordinating a single zinc ion, which stabilizes the conformation needed to promote intra- and extra-thymic T-cell differentiation and to modulate cytokine and neuroendocrine signaling in experimental models. As a metallopeptide, its measured potency tracks zinc availability, a relationship widely examined in vitro. Thymalin, as a multi-peptide thymic extract, is studied for broader immunoregulatory effects on lymphocyte populations and immune homeostasis in cell and animal models rather than through a single defined receptor.

Research Applications

• Zinc-dependent conformation and metallopeptide-activity assays
• T-cell differentiation and thymic-function studies
• Comparative immune-regulation of defined peptide versus thymic extract
• Neuroendocrine-immune signaling models
• Lymphocyte-population and cytokine-modulation research

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Zinc-dependent nonapeptide hormone (thymulin) and thymic-extract complex (thymalin)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Thymulin / Thymalin is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Thymulin / Thymalin is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.