VIP – Vasoactive Intestinal Peptide | Research Grade | COA Verified

Description

Research area: VPAC receptor signaling and neuro-immune research models

Product Description

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide of the secretin/glucagon superfamily, structurally related to PACAP, secretin, and GLP-1. Widely distributed in the central and peripheral nervous systems and the gastrointestinal tract, it functions as a neurotransmitter and neuromodulator with roles spanning vasodilation, smooth-muscle relaxation, circadian regulation, and immune modulation. As an endogenous signaling peptide rather than a synthetic construct, its activity derives from a well-defined receptor interaction. In research it is notable for its broad anti-inflammatory profile and its involvement in suprachiasmatic-nucleus circadian timing, distinguishing it from the metabolic and growth-hormone peptides within its structural family.

Mechanism & Research Context

VIP binds two class B G-protein-coupled receptors, VPAC1 and VPAC2, which couple to Gs and elevate cAMP through adenylate cyclase, activating PKA and downstream CREB phosphorylation. VPAC1 predominates on T cells, macrophages, and lung tissue, driving anti-inflammatory cytokine shifts, while VPAC2 concentrates in the suprachiasmatic nucleus and smooth muscle, influencing circadian phase and motility. Research employs VIP and receptor-selective analogues to study neuroprotection, immune suppression, and enteric and circadian signaling in cell and animal models.

Research Applications

• VPAC1/VPAC2 receptor-binding and cAMP-signaling assays
• Anti-inflammatory cytokine-shift studies in immune cells
• Circadian suprachiasmatic-nucleus signaling models
• Smooth-muscle relaxation and enteric-motility research
• Neuroprotection and neuromodulation investigations

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: 28-amino-acid secretin/glucagon-superfamily neuropeptide
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of VIP – Vasoactive Intestinal Peptide is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

VIP – Vasoactive Intestinal Peptide is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.