PT-141

Description

PT-141, is a highly engineered synthetic peptide derived from alpha-melanocyte-stimulating hormone (α-MSH). Designed through advanced peptide modification, PT-141 offers increased stability and targeted biological activity, setting it apart from naturally occurring α-MSH and earlier melanocortin compounds.

This peptide has undergone formal clinical investigation for conditions related to sexual health, including male and female hypoactive sexual desire disorder (HSDD), making it one of the most extensively studied melanocortin-based peptides in this domain. Unlike traditional therapies that act through hormonal pathways, PT-141 works directly through the central nervous system, targeting neural signaling mechanisms linked to sexual desire and arousal rather than altering systemic hormone levels.

PT-141 functions as an agonist at the melanocortin-4 (MC4R) and melanocortin-1 (MC1R) receptors, two key components of the melanocortin system involved in behavioral regulation, autonomic function, and immune activity. Through MC4R activation in particular, PT-141 has demonstrated the ability to influence arousal pathways in the brain, providing a novel and mechanistically distinct approach to sexual wellness research.

Beyond its effects on arousal, PT-141 has also been studied in clinical contexts related to acute hemorrhage, where melanocortin system activation has been explored for its potential impact on vascular tone, inflammation control, and systemic stress responses. While this area of research is still evolving, it highlights the peptide’s broader relevance across multiple physiological systems.

In laboratory and clinical studies, PT-141 has also shown activity consistent with immune modulation—an additional dimension of interest for researchers studying how melanocortin signaling influences inflammatory and defensive pathways in the body.

With its central nervous system activity, dual receptor targeting, and established research history, PT-141 remains a significant compound in both sexual health science and melanocortin signaling research. Its unique profile continues to make it a valuable model peptide for understanding how targeted receptor activation can drive behavioral and physiological change.

Comes in 10mg Vial

Provided as lyophilized powder intended strictly for experimental and research applications.