MOTS-C

Description

MOTS-c is a mitochondrial-derived peptide (MDP) composed of just 16 amino acids, yet it plays an outsized role in regulating cellular metabolism and energy balance. Unlike most peptides that are produced in the cytoplasm, MOTS-c is synthesized within the mitochondria themselves—the cell’s energy powerhouse—placing it at the very center of metabolic control and cellular performance.

This unique peptide functions as a metabolic signaling molecule that helps the body adapt to energetic and physiological stress. MOTS-c is known to influence key pathways involved in glucose utilization, insulin sensitivity, and cellular stress response, making it a significant focus in advanced metabolic and longevity research. Rather than targeting just one process, MOTS-c acts as a global regulator that helps balance energy production and demand at the cellular level.

What makes MOTS-c especially remarkable is its ability to translocate from the mitochondria into the nucleus. Once inside the nucleus, it directly influences gene expression related to mitochondrial biogenesis, metabolic regulation, and cellular resilience. This “mitochondria-to-nucleus” signaling allows MOTS-c to coordinate energy systems throughout the cell, particularly under conditions of metabolic challenge such as exercise, nutrient stress, or aging.

In research settings, MOTS-c has demonstrated promising effects on improving exercise performance, enhancing metabolic efficiency, and supporting healthier body composition. Investigations have also explored its potential role in reducing insulin resistance, improving glucose handling, and supporting skeletal integrity. These findings have made MOTS-c a compound of strong interest in studies related to metabolic disorders, age-associated decline, and cellular stress adaptation.

Because it operates at such a fundamental biological level, MOTS-c is often described as a bridge between mitochondrial function and gene regulation. Its emerging role in metabolic health research positions it as a next-generation target for understanding how energy balance, aging biology, and cellular defense mechanisms are interconnected.

As scientific exploration continues, MOTS-c stands out as a powerful example of how mitochondrial signaling peptides may shape the future of metabolic optimization, performance science, and longevity research.

Comes in 10mg vial

Provided as lyophilized powder intended strictly for experimental and research applications.