MOTS-C | Research Grade | COA Verified

Description

Research area: Mitochondrial-derived peptide metabolic signaling

Product Description

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame within the mitochondrial 12S ribosomal RNA gene, rather than by the nuclear genome. It was among the first mitochondrial peptides shown to act as a signaling molecule that influences nuclear gene expression and systemic metabolism, exemplifying retrograde mitochondrial-to-nuclear communication. Its expression is reported to rise in response to metabolic stress and exercise, and under such conditions it can translocate to the nucleus. These features make MOTS-c a distinctive research tool for studying how mitochondria encode regulatory peptides that coordinate cellular energy metabolism, stress adaptation, and aging-related processes in cell and animal models.

Mechanism & Research Context

In research models MOTS-c is studied for its action on the folate-methionine cycle and de novo purine biosynthesis, where inhibition promotes accumulation of AICAR, an activator of AMP-activated protein kinase (AMPK). AMPK activation is examined for downstream effects on energy homeostasis, insulin sensitivity, and inflammatory signaling. Under stress, nuclear-translocated MOTS-c is also studied for binding antioxidant-response-element regulatory regions and modulating stress-adaptation gene programs alongside SIRT1 and PGC-1alpha pathways.

Research Applications

• Study of the folate-AICAR-AMPK metabolic signaling axis in vitro
• Rodent models of insulin resistance and glucose metabolism
• Investigation of exercise-mimetic and mitochondrial-stress responses
• Research on nuclear translocation and antioxidant-response gene regulation
• Preclinical aging and metabolic-homeostasis model systems

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Mitochondrial-derived peptide (16-amino-acid)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of MOTS-C is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

MOTS-C is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.