AOD 9604 | Research Grade | COA Verified

Description

Research area: Lipid metabolism and adipocyte research

Product Description

AOD-9604 (Advanced Obesity Drug 9604) is a synthetic peptide corresponding to the C-terminal residues 176-191 of human growth hormone, with an added tyrosine at the N-terminus for stability. It reproduces the lipolytic domain of growth hormone while lacking the regions responsible for growth-promoting and insulin-related activity, so in research models it does not raise IGF-1 or affect blood glucose. This structural isolation is its defining trait, making it a tool for studying fat metabolism independent of the broader GH signaling axis. It was originally developed by Metabolic Pharmaceuticals as a metabolic research peptide.

Mechanism & Research Context

In adipocyte and rodent studies, AOD-9604 is reported to stimulate lipolysis and inhibit lipogenesis by acting on beta-3 adrenergic receptor signaling, elevating intracellular cyclic AMP and activating hormone-sensitive lipase, which hydrolyzes stored triglycerides into free fatty acids and glycerol. Unlike full-length growth hormone, it does not engage the GH receptor's growth or glucose pathways, allowing researchers to isolate fat-mobilization mechanisms across visceral and subcutaneous fat models.

Research Applications

• Lipolysis and lipogenesis assays in adipocyte cultures
• Beta-3 adrenergic receptor and cyclic-AMP signaling studies
• Hormone-sensitive lipase activation research
• Comparative studies versus full-length growth hormone in rodent models
• Preclinical body-composition and fat-mobilization research

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic modified peptide (hGH 176-191 C-terminal fragment)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of AOD 9604 is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

AOD 9604 is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.