ARA-290 | Research Grade | COA Verified

Description

Research area: Neuropathic pain and tissue-protection research

Product Description

ARA-290, also called cibinetide, is a synthetic linear peptide of eleven amino acids whose sequence mimics the helix-B surface of erythropoietin (EPO), the region that mediates EPO’s tissue-protective signaling. Because it reproduces only this surface, it engages the innate repair receptor without triggering EPO’s erythropoietic activity, so in models it does not raise red blood cell counts. This selective, non-hematopoietic design distinguishes it sharply from EPO itself and defines its use as a research tool. It was investigated in clinical trials for sarcoidosis-related small-fiber neuropathy and diabetic neuropathy.

Mechanism & Research Context

ARA-290 selectively activates the innate repair receptor, a heterodimer of the EPO receptor and the beta-common receptor (CD131), which is distinct from the homodimeric EPO receptor that drives red-cell production. In cellular and animal models, receptor engagement triggers anti-inflammatory and cytoprotective signaling; research also links it to modulation of the TRPV1 channel within nociceptive pathways, informing studies of small-fiber neuropathy and inflammatory tissue injury.

Research Applications

• Innate repair receptor (EPOR/CD131) activation studies
• Small-fiber and diabetic neuropathy models
• Anti-inflammatory and cytoprotective signaling research
• TRPV1 channel and nociception investigations
• Non-erythropoietic tissue-protection studies distinct from EPO

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic 11-amino-acid peptide (EPO helix-B mimetic)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of ARA-290 is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

ARA-290 is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.