Cagrilintide | Research Grade | COA Verified

Description

Research area: Amylin signaling and satiety research

Product Description

Cagrilintide (AM833) is a long-acting synthetic analog of amylin, a 37-amino-acid hormone co-secreted with insulin by pancreatic beta cells. Developed by Novo Nordisk, it carries amino-acid substitutions and a lipid (fatty-acid) acylation that extend its half-life, enabling sustained receptor engagement in research models. It functions as a dual amylin and calcitonin receptor agonist rather than a GLP-1 compound, which distinguishes it from semaglutide and other incretin peptides. It has been studied both alone and combined with semaglutide (as CagriSema) to compare and combine distinct satiety-signaling pathways in metabolic research.

Mechanism & Research Context

In preclinical and clinical metabolic research, cagrilintide engages the amylin receptor complex and the calcitonin receptor, acting largely at the area postrema and hypothalamic circuits that regulate satiety, gastric emptying, and energy homeostasis. Because amylin signaling operates through pathways distinct from GLP-1, researchers use cagrilintide to characterize amylin-specific appetite regulation and to model additive effects when it is combined with GLP-1 receptor agonists.

Research Applications

• Amylin and calcitonin receptor agonism studies
• Satiety and gastric-emptying signaling research
• Area postrema and hypothalamic appetite-circuit models
• Additive amylin-plus-GLP-1 pathway studies (CagriSema)
• Long-acting acylated-peptide pharmacokinetic characterization

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Long-acting synthetic amylin analog (acylated peptide)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Cagrilintide is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Cagrilintide is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.