CJC-1295 No DAC | Research Grade | COA Verified

Description

Research area: Growth-hormone-releasing hormone receptor signaling studies

Product Description

CJC-1295 No DAC, also called Modified GRF 1-29, is a synthetic 29-amino-acid analog of the biologically active fragment of growth-hormone-releasing hormone. It carries four amino-acid substitutions relative to native GRF 1-29 (D-Ala at position 2, Gln at 8, Ala at 15, and Leu at 27) that confer resistance to dipeptidyl peptidase-4 and other plasma proteases. Unlike the DAC variant, it lacks the albumin-binding Drug Affinity Complex, giving it a short circulating half-life of roughly thirty minutes. This distinguishes it as a research tool for probing pulsatile, rather than continuous, somatotroph stimulation in preclinical models.

Mechanism & Research Context

In laboratory models the peptide binds the growth-hormone-releasing hormone receptor on pituitary somatotroph cells, coupling through Gs proteins to activate adenylate cyclase and raise intracellular cAMP. This cascade is studied as an upstream driver of growth hormone synthesis and pulsatile release, with downstream effects on the IGF-1 axis. Its protease-resistant, short-acting profile makes it a reference compound for investigating physiological pulse patterns and receptor desensitization in vitro and in animal systems.

Research Applications

• Probing GHRH-receptor binding affinity and cAMP signaling in somatotroph cell assays
• Modeling pulsatile versus continuous growth-hormone secretion dynamics in animal studies
• Investigating DPP-4 resistance conferred by the four amino-acid substitutions
• Comparative pharmacokinetic research against DAC-conjugated CJC-1295 analogs
• Studying downstream IGF-1 axis regulation in preclinical endocrine models

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic GHRH (1-29) analog peptide (Modified GRF 1-29)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of CJC-1295 No DAC is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

CJC-1295 No DAC is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.