DSIP | Research Grade | COA Verified

Description

Research area: Slow-wave sleep and neuromodulation research

Product Description

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, originally isolated in 1977 from the cerebral venous blood of rabbits during electrically induced slow-wave sleep. It is notable for crossing the blood-brain barrier efficiently despite its size, a property that has framed it in research as a candidate circulating neuromodulator. Unlike sedative small molecules, DSIP has no single well-defined receptor, and decades of study describe it as a modulator rather than a direct agonist. This uncertain target profile is precisely what distinguishes it as a research subject.

Mechanism & Research Context

DSIP’s receptor and precise signaling pathway remain incompletely characterized in the literature. Research models describe it as acting across multiple neurotransmitter systems rather than through one defined receptor, with reported influence on serotonergic, glutamatergic, dopaminergic, and melatonin-related signaling. Studies examine concentration- and timing-dependent, sometimes biphasic, effects on delta-wave EEG activity, along with stress-protective, anticonvulsant, and immunomodulatory responses in animal paradigms, consistent with a normalizing neuromodulatory role.

Research Applications

• Investigating delta-wave EEG modulation in animal sleep paradigms
• Characterizing blood-brain-barrier permeability of small neuropeptides
• Screening candidate receptor and neurotransmitter interactions in vitro
• Modeling stress-protective and anticonvulsant responses in rodents
• Studying biphasic, timing-dependent sleep-wake effects in preclinical models

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Endogenous nonapeptide (neuromodulatory peptide)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of DSIP is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

DSIP is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.