Ipamorelin | Research Grade | COA Verified

Description

Research area: Selective ghrelin-receptor growth-hormone secretagogue studies

Product Description

Ipamorelin is a synthetic pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2, derived from the GHRP-1 lineage. It incorporates non-natural and D-amino acids that enhance peptidase resistance and receptor selectivity. Unlike GHRH analogs such as CJC-1295, it acts as a ghrelin-mimetic secretagogue at a different receptor. Its defining research characteristic is selectivity: in models it stimulates growth-hormone release with minimal effect on cortisol, prolactin, or other pituitary hormones, making it a frequently used reference compound for isolating clean growth-hormone-secretagogue signaling.

Mechanism & Research Context

Ipamorelin binds and activates the growth-hormone secretagogue receptor subtype 1a (GHS-R1a), the same receptor targeted by endogenous ghrelin. Receptor activation couples through Gq/11 proteins to phospholipase C, generating IP3 and diacylglycerol and mobilizing intracellular calcium in somatotroph models. This drives selective growth-hormone release, and research exploits its low off-target hormone activity to study pituitary secretagogue signaling in isolation from cortisol and prolactin responses.

Research Applications

• Characterizing GHS-R1a binding and Gq/11-PLC-calcium signaling in vitro
• Studying selective growth-hormone release without cortisol or prolactin stimulation
• Comparative secretagogue research against GHRP and GHRH-analog peptides
• Investigating combined GHRH-analog plus secretagogue signaling in models
• Modeling ghrelin-receptor pharmacology in somatotroph cell systems

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic pentapeptide growth-hormone secretagogue
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Ipamorelin is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Ipamorelin is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.