Mazdutide | Research Grade | COA Verified

Description

Research area: Dual incretin-glucagon metabolic signaling models

Product Description

Mazdutide (also designated IBI362 or LY3305677) is a synthetic peptide engineered as an analogue of oxyntomodulin, a naturally occurring proglucagon-derived hormone. Unlike single-target incretin peptides, it is a unimolecular dual agonist designed to engage two distinct receptors simultaneously. Structural modifications, including fatty-acid conjugation for albumin binding, confer extended circulating stability consistent with once-weekly experimental administration in animal models. As a co-developed candidate from Eli Lilly and Innovent Biologics, it is characterized in the metabolic-research literature as a tool for dissecting the combined contributions of incretin and glucagon-axis signaling, distinguishing it from GLP-1-only comparators frequently used alongside it in preclinical metabolic studies.

Mechanism & Research Context

Mazdutide simultaneously activates the GLP-1 receptor (GLP1R) and the glucagon receptor (GCGR), both class-B G-protein-coupled receptors coupled to cAMP signaling. In research models the GLP1R arm is studied for insulinotropic and satiety-related pathways, while the GCGR arm is investigated for effects on hepatic energy expenditure and lipid handling. This dual engagement lets investigators probe how combined incretin and glucagon signaling jointly influence glucose regulation and energy metabolism in rodent and cell-based systems.

Research Applications

• Preclinical study of combined GLP1R/GCGR activation on energy expenditure
• Rodent models of glucose homeostasis and insulin secretion
• Investigation of hepatic lipid metabolism via glucagon-receptor signaling
• Comparative pharmacology against GLP-1 mono-agonist reference peptides
• In-vitro cAMP receptor-activation and binding-affinity assays

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic oxyntomodulin-analogue dual receptor agonist
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Mazdutide is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Mazdutide is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.