Pinealon | Research Grade | COA Verified

Description

Research area: Neuroprotective peptide bioregulator research

Product Description

Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg (EDR), developed within the Khavinson peptide-bioregulation program at the Saint Petersburg Institute of Bioregulation and Gerontology. It is presented as the defined synthetic equivalent of an active peptide fragment associated with pineal-gland extracts, reformulating a complex natural preparation into a single characterized molecule. As one of the ultra-short bioregulator peptides (two to four residues), it belongs to a class proposed to influence cells through direct nucleic-acid interaction rather than surface-receptor binding. Most supporting data derive from Russian-language cell-culture and rodent studies, and it is handled strictly as a research-grade material for neuroprotection and cellular-stress investigations, not as a licensed medicine.

Mechanism & Research Context

In the proposed research framework, ultra-short peptides such as Pinealon are studied for the ability to penetrate cell and nuclear membranes through energy-independent processes and interact directly with DNA to modulate gene expression, rather than binding cell-surface receptors. In hypoxia and oxidative-stress cell and rodent models, Pinealon is investigated for reducing markers of oxidative damage, limiting apoptotic neuronal death, preserving mitochondrial membrane integrity, and modulating melatonin-related regulatory pathways.

Research Applications

• In-vitro neuronal protection against hypoxia and oxidative stress
• Study of apoptosis markers in stressed neuronal cultures
• Rodent models of hypoxia-induced neuronal damage
• Investigation of peptide-DNA interaction and gene-expression modulation
• Research on mitochondrial membrane integrity under oxidative challenge

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Ultra-short tripeptide bioregulator (Glu-Asp-Arg)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Pinealon is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Pinealon is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.