Retatrutide | Research Grade | COA Verified

Description

Research area: Triple incretin and glucagon receptor signaling

Product Description

Retatrutide (LY3437943) is a synthetic 39-amino-acid, fatty-acid-acylated peptide engineered as a single-molecule agonist at three metabolic receptors: the GLP-1, GIP, and glucagon receptors. Built on an incretin-hormone scaffold with unnatural amino-acid substitutions and a lipid side chain enabling albumin binding and extended circulation, it is distinguished by balanced GLP-1 and glucagon receptor activity layered with prominent GIP receptor engagement. This tri-agonist design lets researchers study the combined and separable contributions of three overlapping signaling axes within one chemical entity, making it a reference tool for dissecting integrated incretin and energy-balance pharmacology in cell and animal metabolic-research models.

Mechanism & Research Context

Retatrutide simultaneously engages GLP-1, GIP, and glucagon receptors, all class B G-protein-coupled receptors that stimulate adenylyl cyclase and cyclic AMP accumulation. In preclinical and cell-based research, GLP-1 and GIP receptor arms are studied for insulinotropic and appetite-signaling readouts, while the glucagon receptor arm is examined for energy-expenditure and hepatic lipid-metabolism pathways. Comparative receptor-potency, cAMP, and beta-arrestin assays are used to characterize its balanced multi-receptor activation profile.

Research Applications

• Comparative EC50 profiling across GLP-1, GIP, and glucagon receptors
• cAMP accumulation and beta-arrestin recruitment assays
• Energy-expenditure and thermogenesis studies in rodent models
• Hepatic lipid and steatosis research in animal metabolic models
• Deconstructing individual receptor-arm contributions to metabolic signaling

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic acylated triple-agonist peptide (GLP-1/GIP/glucagon)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Retatrutide is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Retatrutide is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.