Semax | Research Grade | COA Verified

Description

Research area: Neurotrophic and monoaminergic CNS peptide research

Product Description

Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro, combining the 4-7 fragment of adrenocorticotropic hormone with a C-terminal Pro-Gly-Pro tripeptide that confers resistance to enzymatic degradation. As an ACTH(4-10) analogue in the family of short regulatory neuropeptides, it retains the neurotropic character of the parent fragment while lacking the corticotropic, cortisol-releasing hormonal activity of full-length ACTH. This separation of neuromodulatory from endocrine activity, together with its enhanced enzymatic stability, distinguishes Semax and makes it a frequently used tool compound for studying neurotrophic-factor regulation, cognition-related pathways, and neuroprotective signaling in rodent and cell-culture neuroscience research.

Mechanism & Research Context

In animal and cell studies, Semax modulates brain-derived neurotrophic factor (BDNF) and its TrkB receptor, increasing BDNF protein, TrkB phosphorylation, and exon-specific BDNF and TrkB messenger RNA in the hippocampus. It also engages melanocortin-related pathways and modulates dopaminergic and serotonergic systems. Radiolabeled-binding work indicates specific, reversible interactions. Researchers apply it to probe neurotrophic signaling, monoaminergic tone, and neuroprotective responses in preclinical models.

Research Applications

• BDNF/TrkB expression and phosphorylation assays in hippocampal tissue
• Dopaminergic and serotonergic modulation studies in rodents
• Neuroprotection models under ischemic or oxidative stress
• Melanocortin-pathway signaling investigations distinct from ACTH endocrine effects
• Peptidase-resistance and stability profiling of the Pro-Gly-Pro motif

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic ACTH(4-10) analogue heptapeptide
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Semax is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Semax is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.