Snap-8 Raw | Research Grade | COA Verified

Description

Research area: SNARE modulation research in bulk-powder form

Product Description

This is SNAP-8 (acetyl octapeptide-3) supplied as raw bulk powder rather than a pre-portioned vial, chemically identical to the finished SNAP-8 peptide. It is the synthetic acetylated octapeptide Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp, approximately 1076 Da, modeled on the N-terminal region of SNAP-25, the SNARE protein that supplies two of the four helices in the neuronal fusion complex. As an extended analogue of argireline, it competes for SNARE assembly sites. The unformulated gram-scale powder format suits laboratories requiring their own weighing, reconstitution, and formulation workflows for SNARE-dependent vesicle-fusion and neurotransmitter-release investigations in biochemical and cell-culture research.

Mechanism & Research Context

Chemically identical to vialed SNAP-8, this raw powder mimics the SNAP-25 N-terminus and is studied as a reversible competitor of SNARE four-helix-bundle formation, hindering proper alignment of syntaxin, synaptobrevin, and SNAP-25 helices. Distinct from botulinum toxin's irreversible cleavage, it reduces vesicle-fusion efficiency without abolishing it. The bulk format supports custom concentration series and assay development probing exocytosis and SNARE modulation in neuronal and secretory-cell research systems.

Research Applications

• Custom concentration-series preparation for SNARE-inhibition assays
• Bulk reconstitution and formulation-development workflows
• Neurotransmitter-release quantification across concentration ranges in cell culture
• Analytical characterization (HPLC/MS) of octapeptide identity and purity
• Comparative peptide-mimetic exocytosis studies at scale

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Synthetic acetylated octapeptide, raw bulk powder
• Form: Raw powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Snap-8 Raw is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Snap-8 Raw is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.