Tesamorelin | Research Grade | COA Verified

Description

Research area: Growth-hormone-axis regulation and endocrine signaling research

Product Description

Tesamorelin is a synthetic analogue of human growth-hormone-releasing hormone (GHRH), built on the full 44-amino-acid GRF(1-44) sequence and stabilized by an N-terminal trans-3-hexenoic acid (trans-3-hexenoyl) modification. This lipophilic acylation shields the peptide’s N-terminus from the rapid enzymatic degradation that inactivates native GHRH in plasma, yielding a molecule of roughly 5.1 kDa with extended stability and potent receptor engagement. It is a peptide secretagogue acting upstream of growth-hormone release, distinguished from ghrelin-receptor agonists by targeting the GHRH pathway. It is among the most extensively characterized GHRH analogues in the scientific literature.

Mechanism & Research Context

Tesamorelin binds the GHRH receptor on anterior-pituitary somatotroph cells, a class B G-protein-coupled receptor that couples to Gs and elevates intracellular cAMP through the adenylate-cyclase/PKA cascade. This stimulates synthesis and pulsatile secretion of growth hormone while preserving physiological burst patterns in animal models. Because it acts at the hypothalamic-pituitary level rather than bypassing feedback, research employs it to study GH-axis regulation, downstream IGF-1 dynamics, and lipid metabolism in preclinical systems.

Research Applications

• GHRH-receptor binding and cAMP-signaling assays
• Pulsatile growth-hormone secretion studies in animal models
• IGF-1 axis and endocrine-feedback research
• Comparative potency versus native GHRH in vitro
• Peptide-stability and proteolytic-resistance investigations

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: Stabilized synthetic GHRH (GRF 1-44) analogue peptide
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Tesamorelin is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Tesamorelin is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.