Thymosin Alpha 1 TA-1 | Research Grade | COA Verified

Description

Research area: Innate and adaptive immune-modulation research models

Product Description

Thymosin Alpha-1 (TA-1, thymalfasin) is a 28-amino-acid acetylated peptide originally isolated from thymic tissue as a fragment of the precursor prothymosin alpha. One of the most extensively studied immunomodulatory peptides, it is a defined single-sequence peptide rather than a crude thymic extract, and is approved in numerous countries as an immune adjuvant. Structurally acidic and highly conserved, it acts on innate and adaptive immune cells to shape cytokine output. It is distinguished from mixed thymic preparations such as thymalin and from the actin-binding beta-thymosins, occupying a distinct role in immune-signaling research.

Mechanism & Research Context

Thymosin Alpha-1 signals largely through Toll-like receptors, notably TLR-2 and TLR-9 on dendritic cells and other myeloid populations, engaging MyD88-dependent NF-kappaB and IRF signaling. This promotes dendritic-cell maturation, Th1-polarizing cytokines such as IL-12 and interferons, and enhanced T-cell and NK-cell activity in culture. It also induces indoleamine-2,3-dioxygenase in plasmacytoid dendritic cells, supporting regulatory T-cell balance. Preclinical models use it to study immune restoration, antiviral and antitumor responses, and cytokine modulation.

Research Applications

• Toll-like-receptor (TLR-2/TLR-9) signaling assays
• Dendritic-cell maturation and cytokine-profiling studies
• T-cell and NK-cell activation research in vitro
• Antiviral and antitumor immune-response models
• Regulatory T-cell and IDO-pathway investigations

Storage & Handling

• Store sealed vials in a cool, dark place for short-term storage and frozen for long-term storage.
• After reconstitution, refrigerate and protect from light and heat.
• Avoid repeated freeze-thaw cycles; handle using standard laboratory safety and aseptic technique.

Product Specifications

• Compound class: 28-amino-acid acetylated immunomodulatory peptide (prothymosin-alpha fragment)
• Form: Lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Appearance: White to off-white powder
• Third-party tested: Yes — Certificate of Analysis (COA) on this product page

Quality & Third-Party Testing

Every batch of Thymosin Alpha 1 TA-1 is independently third-party tested in the USA for identity and purity, with a Certificate of Analysis (COA) available on this product page.

Compliance Notice

Thymosin Alpha 1 TA-1 is for research use only. It is not intended for human or veterinary use and has not been evaluated by the FDA. By purchasing, the buyer represents and warrants that it will be used solely for in-vitro laboratory research.